By Category

Supreme Polypeptide Cream with Matrixyl® Synthe’6™

1.2 ozStep 5Age Defense

Nutrient-rich recontouring cream lifts and retexturizes skin for a more refined, youthful appearance.




Product Description

Nutrient-rich recontouring cream lifts and retexturizes skin for a more refined, youthful appearance. Matrixyl® synthe’6™ reduces wrinkle volume by 21% and wrinkle depth by 19% in 8 weeks. Proteasyl® TP Pea Peptide is clinically proven to improve skin’s elasticity, increasing overall firmness by 35% in just 6 weeks. Rice Peptides improve skin smoothness while Syn®-Coll Peptide triggers skin’s own reparative function to accelerate collagen production.

Use with the Peptide+ Anti-Wrinkle Serum for the ultimate age defense.

Chrissy saw a 19% improvement in just one month on her wrinkles score by adding in the Supreme Polypeptide Cream to her regimen.


Palmitoyl Tripeptide-38 (Matrixyl® synthe’6™) is the new and improved version of the popular Matrixyl family of ingredients. This new sophisticated advancement is a clean collaboration of notable ingredients that demonstrate through evidence based research and visual effect a reduction in the volume and depth of a wrinkle. In vitro studies strongly stimulated 6 major structural components of the skin.

Pisum Sativum (Pea Peptide) Extract (Proteasyl TP®) – A botanical anti-enzyme complex to promote firmness and elasticity through the implementation of proteins and essential amino acids that promote the production of collagen. Exhibits antioxidant and anti-wrinkle effects.

Palmitoyl Tripeptide-5 (SYN®-COLL) Peptide – Activates the TGF-beta growth factor to improve the synthesis of collagen, relieves wrinkles, moisturizes and firms. Clinical trials have shown this ingredient to reduce and changes depth of wrinkles.

Aqua (Water), Helianthus Annuus (Sunflower) Seed Oil, Caprylic/Capric Triglyceride (Coconut), Glycerin (Vegetable), Squalane (Olives), Cetearyl Olivate (Olive Oil), Ribes Nigrum (Black Currant) Seed Oil, Cetearyl Alcohol, Mangifera Indica (Mango) Seed Butter, Butyrospermum Parkii (Shea Butter), Polysorbate 60 (Plant), Rosa Canina (Rose Hip) Fruit Oil, Sorbitan Olivate (Olive Oil), C18-36 Acid Triglyceride, Simmondsia Chinensis (Jojoba) Seed Oil, Pisum Sativum (Pea Peptide) Extract (Proteasyl® TP), Palmitoyl Tripeptide-5 (Syn®-Coll), Palmitoyl Tripeptide-38 (Matrixyl® synthe’6™), Hydrolyzed Collagen (Marine Oligopeptides), Hydrolzyed Rice (Peptide) Protein, rh-Oligopeptide-1 (Epidermal Growth Factor), Cassia Angustifolia (Indian Senna) Seed Polysaccharide, Totarol, Astaxanthin (BioAstin®), Camellia Sinensis (Green Tea) Leaf Extract, Elaeis Guineensis (Palm) Oil, Polygonum Cuspidatum (Giant Knotweed/Resveratrol) Extract, Honey (Mel), Phospholipids (Plant), Sphingolipids (Plant), Sodium Hyaluronate (L) (Hyaluronic Acid), Lecithin, Tocotrienols, Tocopherol (D-Alpha), Hamamelis Virginiana (Witch Hazel) Water, Glucosamine HCI (D) (Chinese Foxglove), Cananga Odorata (Ylang Ylang) Flower Oil, Boswellia Carterii (Frankincense) Oil, Rosa Damascena Flower Oil, Citrus Aurantium Amara (Bitter Orange) Flower Oil, Citrus Aurantium Dulcis (Orange) Peel Oil, Lavandula Angustifolia (Lavender) Oil, Xanthan Gum (Fermented Sugar), Hydroxyprophyl Cyclodextrin, Alcohol Denatured (Grain), Jasminum Officinale (Jasmine) Oil, Phenethyl Alcohol (Rose), Caprylyl Glycol (Coconut), Trisodium Ethylenediamine Disuccinate (Green & Biodegradable), Potassium Sorbate (Salt), Citric Acid

How to Use

For youthful, smooth and radiant skin, apply a quarter-size amount to face and neck AM and PM after cleansing, applying serums and misting. Follow with sun protection.


Best cream I've found.

Many of my favorite skincare creams have been discontinued by the department stores. This isn't a department store brand. And there's a reason why. I found this brand at my local health store. Why would anyone ever buy skincare at a department store where you buy clothes and shoes? The ingredients in this cream are the best and very effective.





Changed my life

I can sleep on my side again. Now that I'm over 50 years of age, I'd been learning to sleep only on my back in order to prevent the wrinkling (permanent creases) I was beginning to see forming from sleeping with my face against my pillow. My skin just wasn't bouncing back anymore. I think it was by the time I got to the bottom of one of these jars that I realized one day my skin was firmer around my eyes again, and dramatically so. I sleep however I feel like again, and I continue to use this cream twice a day. I'm starting to use it on other parts of my body, and I am elated that these great results come in a formula that's not overtly bad for my skin like the ingredients in so many skin creams. Don't worry about the price. I did for years. I'm glad I took a gamble one day.


Eugene, OR



couldn't believe it

I first tried this on a 3 hour trip; driving home after a stressful weekend and neglecting myself. Unbelievable- my deep wrinkles could barely be seen, temporarily. I use it daily and have seen some consistent change. Very eager to try the other Age defense products and they both defend and repair, I LOVE IT !!!!

Char J

Weston, WI



A Must Have!

I'm 34 and have dry, sensitive breakout-prone skin. Not an easy combo, but I've been using Supreme Polypeptide Cream at night and Deep Repair Cream during the day - my skin looks (and feels) better than it has in years! My skin feels moisturized, not AT ALL greasy and the breakouts are now almost nonexistent! I too thought I was too young for a cream like this, but now that I've been using it, I wish I started in my 20's. As a bonus, I put a little Supreme Polypeptide Cream on my lips before I go to sleep and it keeps my lips from cracking in the night (a risk in this DRY Colorado winter weather.) LOVE!


Denver, CO



Whos younger?

I have been using Mychelle products for 4 yrs now and no one can guess my correct age of 51 they all guess 35 I am so thankful for allergy safe products that dont harm animals its a total package I have a daughter that looks like my twin and she has more wrinkle than me being 20yrs youngier than myself lovin your stuff!

Patricia Price

Vermilion Ohio



Fantastic cream

I've been using Supreme Polypeptide Cream for about three years and I couldn't do without it. It makes my skin calm, hydrated and flake free. This cream could go head to head with many more expensive brands and come out a winner.

Stephanie Gerard

Roseville, CA




This cream does wonders. Leaves your skin feeling soft, smooth and you can see results within a few weeks. Highly recommend.


New York, NY



No Adverse Reaction On My Sensitive Mature Skin

I have been using the Supreme Polypeptide Cream and the Deep Repair Cream for about a month. The scent is light but will try the unscented next time. This cream is thick, but not as thick as the Deep Repair Cream (both creams go on very smoothly). It is winter time & I seem to reach for the Deep Repair Cream more often as that jar is less than 1/2 full whereas this cream is 3/4 full. I have seen some improvement in my skin using both creams. I've also realized I am using less makeup, my skin is a tad more even toned & possibly smoother. I plan to repurchase both creams.


Los Angeles, CA



No more Flaky Face in the winter

I have been on nasty cortisone produtcs that my Dermatologist has had me on for a few years now trying to stop the flakys on my face. It never worked well at all.Plus had some horrible side effects on my skin. I was turned on to this product at the health store and OMG no more flakes and my skin is so soft and looks so good this winter. Its wonderful thanks so much.

Dian Lord

Sumner, WAshington



Great multi-tasker

I'm only 33 and not exactly in the anti-aging category, but I have difficult combination skin, and as counterintuitive as a "heavier" cream might seem I truly believe this stuff helps my acne. I think it nourishes, strengthens, ,and detoxifies so well that my skin is less stressed and therefore less susceptible to breakouts. I use the lighter-duty Pumpkin Renew Cream in the morning, and this stuff at night. I like the scent, so that, the silky feel, and the knowledge that I'm taking care of myself helps me relax and feel good every night when I use it at bedtime.


San Diego